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KMID : 0371619940100010083
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Journal of Wonkwang Medical Science
1994 Volume.10 No. 1 p.83 ~ p.92
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The Effect of high dose epinephrine during CPR in human victims of cardiac arrest
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Yoo In-Sool
Park Jae-Hwang
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Abstract
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To compare the return of spontaneous circulation(RSC) rates in cardiac arrest treated with standard doses of epinephrine(SDE) or high dose epinephrine(HDE), the author analyzed prospectively 56 adult victims of nontraumatic cardiac arrest visited the Wonkwang University Hospital emergency department from July, 1991 to December, 1993. At the discretion of the treating physician, patients received epinephrine in bolus doses ranging from 1 to 15㎎. HDE was defined as a dose of at least 0.15 ㎎/㎏ : smaller doses were defined as SDE. the patients were grouped as +RSC if they developed a sustained spontaneous palpable pulse or blood pressure and as -RSC if they did not develop a pulse or blood pressure. Patients were also grouped by their presenting rhythm. Potentially perfusing rhythm was electromechanical dissociation or ventricular tachycardia. Nonperfusing rhythm was asystole or ventricular fibrillation. Rates were analyzed using the Chi-square test and the two tailed unpaired t-test(p = 0.185). The effects were greatest in patients with nonperfusing rhythms(p = 0.119). One patient survived to hospital discharge. This study shows that high-dose epinephrine improves initial resuscitation rates in cardiac arrest. Its greatest effect is in patients with a nonperfusing rhythm.
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